The building is designed as a multipurpose facility that can host more than 100 people. Plans include a conference room for smaller meetings and storage space.
The American Cancer Society estimates about 18,000 new cancer cases will be diagnosed in Mississippi this year. The most common types include prostate, lung and bronchus, and breast cancers.
District officials said more than 50 families could be affected by the rezoning, which aims to balance enrollment between schools serving the St. Martin and Vancleave communities.
The partnership between Cornerstone Counseling and Venture Church marks the organization's fifth counseling center since 2012 and its first in South Mississippi.